This study addresses the issue of the historical occurrences of Muslim genocide in Spain and in Palestine, examining their enduring impact on human civilization. This study emphasizes the need for continuous and in-depth research to understand the causes of these genocide events, with the ultimate goal of developing strategies to prevent such events. Moreover, this study aims to explore these genocides more thoroughly and objectively, focusing on aspects that might have been overlooked or is inadequately covered in previous research. Furthermore, the study aims to compare the genocides in Spain and Palestine, revealing the pattern and common factors that might be significant in understanding the causes of the genocides, as well as potentially identifying unique elements in each case. Such comparative analysis is valuable in developing a more nuanced and comprehensive understanding of the causes of genocides, thereby contributing to the development of strategies to prevent such atrocities in the future. It is largely agreed upon that European Member Countries interfered in the Muslim regions with trade routes important for world trade; these are oceanic straights. Numerous reports, news and historical accounts and researches have been used to carry out this research and analysis of the data. Qualitative research design based on critical instance case study methodology is used to better understand and address the issue. This methodology involves analysis of the causes and dynamics of specific instances of Muslim genocide in Spain and Palestine to gain a deeper understanding of a broader issue.